| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Baker Mayfield |
1. Baker Mayfield, QB | TB | W 51-27 at NO | 24 | 36 | 325 | 4 | 3 | 1 | 0 | 97.6 |
| 2. Lamar Jackson, QB | BAL | W 30-23 vs. WSH | 20 | 26 | 323 | 1 | 1 | 2 | 0 | 114.7 | |
| 3. Jared Goff, QB | DET | W 47-9 at DAL | 18 | 25 | 315 | 3 | 0 | 2 | 0 | 153.8 | |
| 4. Geno Smith, QB | SEA | L 36-24 vs. SF | 30 | 52 | 312 | 1 | 2 | 1 | 0 | 65.5 | |
| 5. Jayden Daniels, QB | WSH | L 30-23 at BAL | 24 | 35 | 269 | 2 | 0 | 3 | 0 | 110.3 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Sean Tucker |
1. Sean Tucker, RB | TB | W 51-27 at NO | 14 | 136 | 9.7 | 1 | 36 | 0 | |
| 2. Derrick Henry, RB | BAL | W 30-23 vs. WSH | 24 | 132 | 5.5 | 2 | 27 | 0 | ||
| 3. Najee Harris, RB | PIT | W 32-13 at LV | 14 | 106 | 7.6 | 1 | 36 | 0 | ||
| 4. Tyler Allgeier, RB | ATL | W 38-20 at CAR | 18 | 105 | 5.8 | 1 | 20 | 0 | ||
| 5. Joe Mixon, RB | HOU | W 41-21 at NE | 13 | 102 | 7.8 | 1 | 59 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Zay Flowers |
1. Zay Flowers, WR | BAL | W 30-23 vs. WSH | 9 | 132 | 14.7 | 0 | 44 | 0 | |
| 2. Chris Godwin, WR | TB | W 51-27 at NO | 11 | 125 | 11.4 | 2 | 55 | 0 | ||
| 3. A.J. Brown, WR | PHI | W 20-16 vs. CLE | 6 | 116 | 19.3 | 1 | 40 | 0 | ||
| 4. Evan Engram, TE | JAX | L 35-16 at CHI | 10 | 102 | 10.2 | 0 | 24 | 1 | ||
| 5. Deebo Samuel Sr., WR | SF | W 36-24 at SEA | 3 | 102 | 34.0 | 1 | 76 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Patrick Queen |
1. Patrick Queen, LB | PIT | W 32-13 at LV | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 |
| 2. Brandon Jones, S | DEN | L 23-16 vs. LAC | 11 | 1 | 12 | 0.0 | 0 | 0 | 0 | |
| 3. Nakobe Dean, LB | PHI | W 20-16 vs. CLE | 7 | 5 | 12 | 0.0 | 0 | 0 | 0 | |
| 4. Bobby Wagner, LB | WSH | L 30-23 at BAL | 6 | 6 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Quay Walker, LB | GB | W 34-13 vs. ARI | 10 | 1 | 11 | 0.0 | 0 | 0 | 0 | |